Course image PHARM-303 Pharmacology and Therapeutics-II
3rd year A PharmD
Course Learning Outcomes (CLOs)
• On completion of this course, students will be able to:
• Explain the etiology of disease and classify the drugs used for its treatment. Describe the mechanism of action of drugs.
• Discuss pharmacokinetics, indications, contraindications, dose & dosage, adverse effects, cautions, precautions, and drug-drug & drug-food interactions.
Course Contents
1. Drugs Acting on Central Nervous System
a. Sedatives & Hypnotics
b. Anxiolytics, Antidepressants and Antimanic drugs
c. Antiepileptics
d. Antiparkinsonian drugs and drugs used in other neurodegenerative diseases
e. Antipsychotics
f. Opioid Analgesics
g. Therapeutic gases: Oxygen, Carbon dioxide, Nitric oxide, Helium
h. CNS Stimulants: Cerebral, Medullary, Spinal Cord Stimulants
i. Anesthetics: General and Local
2. Non Steroidal Anti-Inflammatory Drugs (NSAIDs)
Disease Modifying Antirheumatic Drugs (DMARDs) Non-opioid Analgesics Drugs used in the treatment of Gout
3. Chemotherapy Basic principles of chemotherapy Antibacterials: Folate antagonists: Sulphonamides Cell wall synthesis inhibitors: Penicillin, Cephalosporins, Carbapenem, Monobactam
4. Protein synthesis inhibitors: Aminoglycosides, Tetracyclines, Chloramphenicol, Macrolides Nucleic acid synthesis inhibitors: Quinolones Miscellaneous Antibiotics Antimycobacterial drugs Urinary tract antiseptics Antifungals Antivirals Antiprotozoals: Antimalarials, Anti-amoebiasis, Anthelmintics, Anti-leishmanials Antineoplastic drugs
5. Immunopharmacology Pharmacology of Immunosuppressants Pharmacology of Immunostimulants 6. Toxicology
a. Pollution and its types: Water, Air, Food
b. Poison and principles of treatment of poisoning
c. Poisoning – Signs, Symptoms & Treatment: Ethanol, Barbiturates, Digitalis, Salicylates, Strychnine, Narcotics, Nicotine, Paracetamol, Benzodiazepines, Organophosphorous compounds
d. Chelating agents and their role in poisoning: Dimercaprol, Calcium disodium edetate, Penicillamine, Deferoxamine
Note: For each drug class, students must cover: Classification, Mechanism of Action, Pharmacokinetics, Indications, Contraindications, Dose & Dosage, Adverse Effects, Cautions & Precautions, Drug Interactions.
• On completion of this course, students will be able to:
• Explain the etiology of disease and classify the drugs used for its treatment. Describe the mechanism of action of drugs.
• Discuss pharmacokinetics, indications, contraindications, dose & dosage, adverse effects, cautions, precautions, and drug-drug & drug-food interactions.
Course Contents
1. Drugs Acting on Central Nervous System
a. Sedatives & Hypnotics
b. Anxiolytics, Antidepressants and Antimanic drugs
c. Antiepileptics
d. Antiparkinsonian drugs and drugs used in other neurodegenerative diseases
e. Antipsychotics
f. Opioid Analgesics
g. Therapeutic gases: Oxygen, Carbon dioxide, Nitric oxide, Helium
h. CNS Stimulants: Cerebral, Medullary, Spinal Cord Stimulants
i. Anesthetics: General and Local
2. Non Steroidal Anti-Inflammatory Drugs (NSAIDs)
Disease Modifying Antirheumatic Drugs (DMARDs) Non-opioid Analgesics Drugs used in the treatment of Gout
3. Chemotherapy Basic principles of chemotherapy Antibacterials: Folate antagonists: Sulphonamides Cell wall synthesis inhibitors: Penicillin, Cephalosporins, Carbapenem, Monobactam
4. Protein synthesis inhibitors: Aminoglycosides, Tetracyclines, Chloramphenicol, Macrolides Nucleic acid synthesis inhibitors: Quinolones Miscellaneous Antibiotics Antimycobacterial drugs Urinary tract antiseptics Antifungals Antivirals Antiprotozoals: Antimalarials, Anti-amoebiasis, Anthelmintics, Anti-leishmanials Antineoplastic drugs
5. Immunopharmacology Pharmacology of Immunosuppressants Pharmacology of Immunostimulants 6. Toxicology
a. Pollution and its types: Water, Air, Food
b. Poison and principles of treatment of poisoning
c. Poisoning – Signs, Symptoms & Treatment: Ethanol, Barbiturates, Digitalis, Salicylates, Strychnine, Narcotics, Nicotine, Paracetamol, Benzodiazepines, Organophosphorous compounds
d. Chelating agents and their role in poisoning: Dimercaprol, Calcium disodium edetate, Penicillamine, Deferoxamine
Note: For each drug class, students must cover: Classification, Mechanism of Action, Pharmacokinetics, Indications, Contraindications, Dose & Dosage, Adverse Effects, Cautions & Precautions, Drug Interactions.